Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds

This study provided important insights into the relationship among dynamics, enzyme catalysis and stability, and will be useful in the designing new enzymes with co-evolution of stability, activity and selectivity.PMID:38582485 | DOI:10.1016/j.ijbiomac.2024.131415
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research