Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds
This study provided important insights into the relationship among dynamics, enzyme catalysis and stability, and will be useful in the designing new enzymes with co-evolution of stability, activity and selectivity.PMID:38582485 | DOI:10.1016/j.ijbiomac.2024.131415
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Zhongji Pu Jiawen Cao Wenhui Wu Zhongdi Song Lirong Yang Jianping Wu Haoran Yu Source Type: research