Essential role of Alix in regulating cardiomyocyte exosome biogenesis under physiological and stress conditions
Exosomes released by cardiomyocytes are essential mediators of intercellular communications within the heart, and various exosomal proteins and miRNAs are associated with cardiovascular diseases. However, whether the endosomal sorting complex required for transport (ESCRT) and its key component Alix is required for exosome biogenesis within cardiomyocyte remains poorly understood.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Xinjian Wang, Shuxian Han, Jinxiu Liang, Chen Xu, Ranran Cao, Shuoyang Liu, Yi Luan, Ying Gu, Peidong Han Source Type: research