Essential role of Alix in regulating cardiomyocyte exosome biogenesis under physiological and stress conditions

Exosomes released by cardiomyocytes are essential mediators of intercellular communications within the heart, and various exosomal proteins and miRNAs are associated with cardiovascular diseases. However, whether the endosomal sorting complex required for transport (ESCRT) and its key component Alix is required for exosome biogenesis within cardiomyocyte remains poorly understood.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research