Strategies for developing phages into novel antimicrobial tailocins

This article reviews three strategies for producing tailocins: disrupting the capsid-tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.PMID:38580606 | DOI:10.1016/j.tim.2024.03.003
Source: Trends in Microbiology - Category: Microbiology Authors: Source Type: research