The magnitude of the plasma hepcidin response to oral iron supplements depends on the iron dosage

CONCLUSION: We found a dose-dependent effect of iron supplementation on plasma hepcidin levels. Lower iron dosage results in a smaller increase in hepcidin and might thus lead to more efficient intestinal iron absorption and fewer side effects. The effectiveness and side effects of low-dose iron treatment in women with iron deficiency should be further investigated. This study was registered at the Swiss National Clinical Trials Portal (2021-00312) and ClinicalTrials.gov (NCT04735848).PMID:38579297 | DOI:10.57187/s.3635

Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Maximilian Karczewski Stana Simic Lanja Saleh Albina Nowak Morton G Schubert Diego Moretti Dorine W Swinkels Felix Beuschlein Paolo M Suter Pierre-Alexandre Krayenbuehl Source Type: research