The effect of administering preprocedural VITamin K on the international normalized ratio in patients anticoagulated with ACEnocoumarol (VITKACE-study)

CONCLUSIONS: Using oral vitamin K while patients continue acenocoumarol intake is an effective way to adequately lower INR before an invasive procedure. Low amount of bleeding complications and absence of thromboembolic complications suggest that this is a safe strategy. The INR-values returned gradually to therapeutic range after the procedure, probably contributing to the observed low bleeding rate.PMID:38580096 | DOI:10.1016/j.jtha.2024.03.016

Source: Thrombosis and Haemostasis - April 5, 2024 Category: Hematology Authors: Stella Bijkerk Harm J Lourens Wout G N Mares Corine A van Kampen Maurits J van der Veen Henk J Adriaansen Erik D Ponfoort Barbara Festen G Wouter Westendorp J örgen M P Rovers Gerie M C Groot Hans-Peter R Bootsma Linde M Amelung Sander Bins Gerjo Velders Source Type: research