Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium

Histone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Histone methyltransferases EZH1, EZH2, and demethylases UTX, JMJD3, and UTY catalyse trim...

Source: Cardiovascular Diabetology - April 5, 2024 Category: Cardiology Authors: Julia S ánchez-Ceinos, Shafaat Hussain, Abdul Waheed Khan, Liang Zhang, Wael Almahmeed, John Pernow and Francesco Cosentino Tags: Research Source Type: research