Expansion of HLA ‐DR Positive Peripheral Helper T and Naive B cells in Anticitrullinated Protein Antibody‐Positive Individuals At Risk for Rheumatoid Arthritis

ConclusionThe expansion of HLA-DR+ Tph cells and CXCR5−CD11c−CD38+ naive B cells in ACPA+ individuals, including those who developed inflammatory arthritis and classified RA, supports a key role of these cells in transition from pre-RA to classified RA. These findings may identify a new mechanistic target for treatment and prevention in RA.

https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.42839?af=R

Source: Arthritis and Rheumatology - April 6, 2024 Category: Rheumatology Authors: Hideto Takada, M. Kristen Demoruelle, Kevin D. Deane, Shohei Nakamura, Yasuhiro Katsumata, Katsunori Ikari, Jane H. Buckner, William H. Robinson, Jennifer A. Seifert, Marie L. Feser, LauraKay Moss, Jill M. Norris, Masayoshi Harigai, Elena W. Tags: Full Length Source Type: research