Effective in vitro evaluation of the risk of histamine release related to valemetostat tosylate using MRGPRX2-expressing cells

In conclusion, an in vitro assay using human and animal MRGPRX2-expressing cells would be an effective platform to investigate the mechanism and predict the human risk of histamine release observed in nonclinical studies.PMID:38556353 | DOI:10.2131/jts.49.163

Source: Journal of Toxicological Sciences - March 31, 2024 Category: Toxicology Authors: Eri Hamamura-Yasuno Junzo Kinoshita Koichi Goto Kazunori Fujimoto Michael Pignatello Yoshimi Tsuchiya Kazuhiko Mori Source Type: research