The potential of phosphorylated α-synuclein as a biomarker for the diagnosis and monitoring of multiple system atrophy

CONCLUSION: The p-syn stands out as a promising biomarker for MSA. It is found in oligodendrocytes and shows a correlation with disease severity and progression. However, further research and validation studies are necessary to establish p-syn as a reliable biomarker for MSA. If proven, p-syn could significantly contribute to early diagnosis, disease monitoring, and assessing treatment response.PMID:38572788 | PMC:PMC10993367 | DOI:10.1111/cns.14678

Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Toufik Abdul-Rahman Ranferi Eduardo Herrera-Calder ón Arjun Ahluwalia Andrew Awuah Wireko Tomas Ferreira Joecelyn Kirani Tan Maximillian Wolfson Shankhaneel Ghosh Viktoriia Horbas Vandana Garg Asma Perveen Marios Papadakis Ghulam Md Ashraf Athanasios Ale Source Type: research