Rationale and design of the SPRING trail: effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine, a multicenter, randomized and open-label trail

Migraine is a leading cause of disability worldwide. Several retrospective studies have suggested that the closure of the Patent Foramen Ovale (PFO) may provide relief from migraines. However, three randomized...

Source: BMC Cardiovascular Disorders - April 5, 2024 Category: Cardiology Authors: Yang Zi-yang, Li Hezhi, Luo Dongling, Wang Ximeng and Zhang Caojin Tags: Study Protocol Source Type: research