Association Between the Endocannabinoid System-Related Gene Variants and Epilepsy

In this study, we focused on investigating the connection between genetic variations in genes related to the ECS and the occurrence of epilepsy. Some ECS-related gene variants were selected and genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism (PCR –RFLP) technique. Interestingly,CNR1 rs12720071 genotype (OR 16.33, 95% CI 1.8 –149;p = 0.001) showed an association with generalized epilepsy andMGLL rs604300 genotype (OR 2, 95% CI 1.1 –3.4;p = 0.013) demonstrated a relationship with females diagnosed with focal epilepsy. So, studyingCNR1,MGLL, and their genetic variations provides insights into the role of the endocannabinoid system in health and diseases. Moreover, they hold the potential to pave the way for the development of novel therapeutic approaches specifically targeting them.
Source: Molecular Neurobiology - Category: Neurology Source Type: research