Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells

CONCLUSIONS: Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL-17A/TNF-mediated induction of mesothelial-mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.PMID:38566518 | PMC:PMC10988119 | DOI:10.1002/ctm2.1604

Source: Genomics Proteomics ... - April 3, 2024 Category: Genetics & Stem Cells Authors: Felix Neuhaus Sonja Lieber Veronika Shinkevich Anna Mary Steitz Hartmann Raifer Kathrin Roth Florian Finkernagel Thomas Worzfeld Andreas Burchert Corinna Keber Andrea Nist Thorsten Stiewe Silke Reinartz Vanessa M Beutgen Johannes Graumann Kim Pauck Holger Source Type: research