Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway

CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939

Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research