Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-kappabeta/TNF-alpha Axis in Breast Cancer

This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic biomarkers of breast cancer, pointing to the role of NF-κβ and TNF-α expression in miR-155 and miR-375 expression as therapeutic targets of breast cancer in the future.PMID:38577133 | PMC:PMC10987425 | DOI:10.1007/s12291-022-01101-4
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research