Poor association between 13-valent pneumococcal conjugate vaccine-induced serum and mucosal antibody responses with experimental Streptococcus pneumoniae serotype 6B colonisation

CONCLUSION: This study demonstrates that despite high PCV13 efficacy against experimental Spn6B carriage in young, healthy Malawian adults, robust vaccine-induced systemic and mucosal anti-Spn6B CPS binding antibodies did not directly relate to protection.PMID:38570270 | DOI:10.1016/j.vaccine.2024.03.055

Source: Vaccine - April 3, 2024 Category: Allergy & Immunology Authors: G Tembo M Mayuni R Kamng'ona L Chimgoneko G Chiwala S Sichone B Galafa F Thole C Mkandawire A E Chirwa E Nsomba V Nkhoma C Ngoliwa N Toto L Makhaza A Muyaya E Kudowa M Y R Henrion D Dula B Morton T Chikaonda S B Gordon K C Jambo Source Type: research