Effectiveness of phototherapy with and without probiotics for the treatment of indirect hyperbilirubinaemia in preterm neonates: a randomised controlled trial

CONCLUSION: Oral probiotics (Saccharomyces boulardii) have a significant effect on the duration of phototherapy for neonatal hyperbilirubinaemia, and they decrease the chances of nosocomial infection. Exploration of clinical outcomes by investigating faecal flora and undertaking large randomised controlled trials of various probiotics are needed.ABBREVIATIONS: ABE: acute bilirubin encephalopathy; CNS: central nervous system; GA: gestational age; IVIG: intravenous immunoglobulin; KSD: kernicterus; NNU: neonatal unit; RCT: randomised controlled trial; S. boulardii: Saccharomyces boulardii.PMID:38482867 | DOI:10.1080/20469047.2024.2328416

Source: Paediatrics and international child health - March 14, 2024 Category: Pediatrics Authors: Hisham Nassif Meshari Alaifan Shadi Tamur Khalid Khadawardi Ammar A Bahauddin Aijaz Ahmed Sarfraz Ahmad Rajinder Singh Bakr H Alhussaini Amber Hassan Source Type: research