Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study

CONCLUSIONS: Infants with NE exposed to risk factors for early-onset infection did not have worse short-term adverse outcomes.IMPACT: Risk factors for early-onset neonatal infection, including rupture of membranes >18 h, maternal group B streptococcus colonization, chorioamnionitis, maternal pyrexia or antepartum antibiotics, were not associated with death or short-term morbidity after cooling for NE. Despite exposure to risk factors for early-onset neonatal infection, infants with NE reached oral feeds earlier and needed fewer anti-seizure medications for a shorter duration than infants with NE but without such risk factors. This study supports current provision of therapeutic hypothermia for infants with NE and any risk factors for early-onset neonatal infection.PMID:38565915 | DOI:10.1038/s41390-024-03157-9

Source: Pediatric Research - April 2, 2024 Category: Pediatrics Authors: David Odd Hemmen Sabir Simon A Jones Chris Gale Ela Chakkarapani Source Type: research