Analytical and behavioral characterization of 1 ‐dodecanoyl‐LSD (1DD‐LSD)

This study presents analytical and pharmacological data obtained for 1-dodecanoyl-LSD (1DD-LSD), a novelN1-acylated LSD derivative. The mouse head-twitch response data confirmed that 1DD-LSD produces LSD-like effects though the increasedN1-acyl chain length led to noticeable reduction in potency (ED50 = 3.60 μmol/kg) compared to lower homologues. Abstract1-Acetyl-N,N-diethyllysergamide (1A-LSD, ALD-52) was first synthesized in the 1950s and found to produce psychedelic effects similar to those of LSD. Evidence suggests that ALD-52 serves as a prodrug in vivo and hydrolysis to LSD is likely responsible for its activity. Extension of theN1-alkylcarbonyl chain gives rise to novel lysergamides, which spurred further investigations into their structure –activity relationships. At the same time, ALD-52 and numerous homologues have emerged as recreational drugs (“research chemicals”) that are available from online vendors. In the present study, 1-dodecanoyl-LSD (1DD-LSD), a novelN1-acylated LSD derivative, was subjected to analytical characterization and was also tested in the mouse head-twitch response (HTR) assay to assess whether it produces LSD-like effects in vivo. When tested in C57BL/6J mice, 1DD-LSD induced the HTR with a median effective dose (ED50) of 2.17  mg/kg, which was equivalent to 3.60 μmol/kg. Under similar experimental conditions, LSD has 27-fold higher potency than 1DD-LSD in the HTR assay. Previous work has shown that other homologues such as ALD...
Source: Drug Testing and Analysis - Category: Drugs & Pharmacology Authors: Tags: SHORT COMMUNICATION Source Type: research