The VEGF-Hypoxia Signature is Upregulated in Basal like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer

CONCLUSIONS: These data provide further evidence for breast cancer heterogeneity across diverse populations and molecular subtypes. Interventions selectively targeting VEGF-hypoxia and the immune microenvironment have the potential to improve overall survival in aggressive breast cancers that disproportionately impact Black women in the African Diaspora.PMID:38564595 | DOI:10.1158/1078-0432.CCR-23-1526

Source: Clinical Breast Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Yoo Jane Han Siyao Liu Ashley Hardeman Padma Sheila Rajagopal Jeffrey Mueller Galina Khramtsova Ayodele Sanni Mustapha A Ajani Wendy Clayton Ian W Hurley Toshio F Yoshimatsu Yonglan Zheng Joel Parker Charles M Perou Olufunmilayo I Olopade Source Type: research