GSE242381 Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Contributors : Sarah M Mohr ; Rafael Dai Pra ; Maryann P Platt ; Viktor V Feketa ; Marya Shanabrough ; Luis Varela ; Ashley Kristant ; Haoran Cao ; Dana K Merriman ; Tamas L Horvath ; Sviatoslav N Bagriantsev ; Elena O GrachevaSeries Type : Expression profiling by high throughput sequencingOrganism : Ictidomys tridecemlineatusMammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels lasts for 5 –7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24–48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger drive during IBAs. We further demo nstrate that squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons have reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Ictidomys tridecemlineatus Source Type: research