GSE246896 EGFR is a target of the tumor suppressor E3-ligase FBXW7

Contributors : Matteo Boretto ; Maarten Geurts ; Shashank Gandhi ; Ziliang Ma ; Nadzeya Staliarova ; Martina Celoti ; Sangho Lim ; Gui-Wei He ; Rosemary Millen ; Else Driehuis ; Harry Begthel ; Lidwien Smabers ; Jeanine Roodhart ; Johan van Es ; Wei Wu ; Hans CleversSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFBXW7 is and E3 ubiquitin ligase and is highly mutated in colorectal cancer. We used human colon organoids with engineered FBXW7 hotspot mutations to investigate novel targets of E3 ligase activity with a combined transcriptomic and proteomic approach uncovering the EGFR-MAPK pathway as highly regulated by the E3 ligase activity.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research