13. Sex Hormone Replacement Therapy and Bleeding Patterns among Adolescents and Young Adult Females with Prader-Willi Syndrome: A Retrospective Chart Review

Prader-Willi Syndrome (PWS) is a genetic imprinting syndrome associated with high rates of endocrinopathies such as growth hormone deficiency, thyroid dysfunction, and primary and central hypogonadism. True puberty is absent, delayed, or incomplete in many individuals with PWS, although premature adrenarche is common. The literature on hypogonadism in females with PWS is sparse and no guidelines exist for hypogonadism treatment. We aimed to characterize bleeding patterns and current practices of hormone replacement therapy (HRT) in adolescent and young adult PWS females at a single center in order to inform the development of future studies to improve health outcomes for this population.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research