Pillar[6]MaxQ functions as an < em > in vivo < /em > sequestrant for rocuronium and vecuronium

Chem Commun (Camb). 2024 Mar 28. doi: 10.1039/d4cc00772g. Online ahead of print.ABSTRACTThe binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.PMID:38546190 | DOI:10.1039/d4cc00772g

Source: Chemical Communications - March 28, 2024 Category: Chemistry Authors: Wanping Zhang Emmanuel A Bazan-Bergamino Anton P Doan Xiangjun Zhang Lyle Isaacs Source Type: research