Zeta potential of Z-DNA: A new signature to study B-Z transition in linear and branched DNA

In this study, for the first time we discover the zeta potential difference between B-DNA and lanthanum chloride-induced Z-DNA. A series of linear repeat i.e. (CG)n and (GC)n DNA as well as branched DNA (bDNA) structures was used for the B-to-Z DNA transition. Herein, the positive zeta potential of Z-DNA has been demonstrated as a powerful tool to discriminate between B-form and Z-form of DNA. The generality of the approach has been validated both in linear and bDNA nanostructures. Thus, we suggest zeta potential can be used as an ideal signature for the left-handed Z-DNA.PMID:38554916 | DOI:10.1016/j.ijbiomac.2024.131238
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research