Melanoma in the Breast: A Diagnostic Challenge

Yale J Biol Med. 2023 Dec 29;96(4):475-479. doi: 10.59249/WPKX7733. eCollection 2023 Dec.ABSTRACTAlthough rare, breast metastases can mimic primary tumors, both clinically, radiologically, and histopathologically. Melanoma is a highly metastasizing tumor, and it is known as a great mimicker of tumors. Metastatic melanoma in the breast can mimic primary breast cancer and pose a diagnostic challenge. In most cases, it is associated with disseminated disease and a poor prognosis, therefore, histologic, immunohistochemical and clinical correlation is crucial in diagnosing these cases. In this case report, we discuss a 63-year-old female who presented with clinical features of probable breast cancer, describe immunohistochemistry workup, and discuss pitfalls in interpretation.PMID:38161576 | PMC:PMC10751864 | DOI:10.59249/WPKX7733
Source: The Yale Journal of Biology and Medicine - Category: Universities & Medical Training Authors: Source Type: research