SETD2 Promotes Megakaryocyte Polyploidization and Platelet Generation through Methylation of α-tubulin

CONCLUSION: These findings identify a previously unrecognized role for SETD2 in regulating megakaryopoiesis and highlight the potential of targeting SETD2 to increase platelet production from human cells for transfusion practices.PMID:38537781 | DOI:10.1016/j.jtha.2024.03.010

Source: Thrombosis and Haemostasis - March 27, 2024 Category: Hematology Authors: Lei Chen Jingkun Liu Kunying Chen Yanxun Su Yihe Chen Ying Lei Jia Si Jie Zhang Zhaojun Zhang Weiguo Zou Xiaohui Zhang Matthew T Rondina Qian-Fei Wang Yueying Li Source Type: research