Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
CONCLUSIONS: Integrating human observational studies and genetic causal inference highlights several key pathways in PAD pathophysiology. This work demonstrates that a substantial portion of biomarkers identified in observational studies are not well supported by human genetic evidence and emphasizes the importance of triangulating evidence to understand PAD pathophysiology. Although the identified biomarkers offer insights into atherosclerotic development in the lower limb, their specificity to PAD compared with more widespread atherosclerosis requires further study.PMID:38545784 | DOI:10.1161/ATVBAHA.124.320674
Source: Atherosclerosis - Category: Cardiology Authors: Pranav Sharma Derek Klarin Benjamin F Voight Philip S Tsao Michael G Levin Scott M Damrauer Source Type: research