Partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy in mice lacking thyroid hormone receptor β

CONCLUSIONS: The phenotyping of TRβ-KO mice conducted at thermoneutrality allows novel insights on the role of TRβ in cardiac functions in absence of the usual confounding hyperthyroidism. Even though TRβ is expressed at lower levels than TRα1 in the heart, our findings demonstrate an important role for this isoform in the cardiac response to thyroid hormones.PMID:38526409 | DOI:10.1089/thy.2023.0638

Source: Thyroid : official journal of the American Thyroid Association - March 25, 2024 Category: Endocrinology Authors: Riccardo Dore Sarah Christine Sentis Kornelia Johann Nuria Lopez Alcantara Julia Resch Akila Chandrasekar Helge M üller-Fielitz Lars Christian Moeller Dagmar F ührer Markus Schwaninger Benedikt Obermayer Robert Opitz Jens Mittag Source Type: research