Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway

In this study, we demonstrated that STING activation enhanced the expression of CD73 and the subsequent production of adenosine in immune cells and cancer cells. Mechanistically, the feedback activation of CD73 depended on the type I IFN/IFNAR axis induced by STING activation. Furthermore, the combination of STING agonist and anti-CD73 mAb markedly blocked tumor growth in vivo by promoting the infiltration of CD8+ T cells and reducing the accumulation of Foxp3+ regulatory T cells (Tregs) in the tumor microenvironment. Our work provides a rationale for the combination of STING agonists and CD73 inhibitors in cancer immunotherapy.PMID:38531218 | DOI:10.1016/j.bbrc.2024.149814
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research