A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein

The transcribed ultraconserved region (T-UCR) belongs to a new type of lncRNAs that are conserved in homologous regions of the rat, mouse and human genomes. A lot of research has reported that differential expression of T-UCRs can influence the development of various cancers, revealing the ability of T-UCRs as new therapeutic targets or potential cancer biomarkers. Most studies on the molecular mechanisms of T-UCRs in cancer have focused on ceRNA regulatory networks and interactions with target proteins, but the present study reveals an innovative dual-targeted regulatory approach in which T-UCRs bind directly to mRNAs and directly to proteins.

Source: Translational Research - March 27, 2024 Category: Research Authors: Sixian Chen, Qingyun Zhao, Ruirui Zhang, Jungang Liu, Wenyi Peng, Haotian Xu, Xiaofei Li, Xin Wang, Shuilian Wu, Gang Li, Aruo Nan Source Type: research