The influence of SARS-CoV-2 on the immune system elements and on the placental structure. Clinical, histological and immunohistochemical study

CONCLUSIONS: This study shows that the invasion of SARS-CoV-2 in the placenta can produce significant structural changes, with a decrease in placental vascular density that can have significant implications on proper fetal perfusion. Also, the presence of immunoreactivity at the level of decidua, the placental villi, as well as the chorionic plate proves that the virus can overcome the maternal-fetal barrier. However, in the analyzed cases there were no fetal infections at birth, which may show that local placental factors can be a protective filter for the fetus.PMID:38184836 | PMC:PMC10863699 | DOI:10.47162/RJME.64.4.12

Source: Romanian Journal of Morphology and Embryology - January 7, 2024 Category: General Medicine Authors: Cristina Jana Busuioc Gabriela Camelia Ro şu George Lucian Zoril ă Lauren ţiu Mogoantă Anca Maria Istrate-Ofi ţeru Daniel Pirici Ilona Mihaela Liliac Larisa Iovan Elena Iuliana Anamaria Berbecaru Maria Cristina Com ănescu Sergiu Marian Cazacu Domini Source Type: research