Physical activity modified association of urinary metals mixture and fasting blood glucose in children: From two panel studies

Environ Res. 2024 Mar 23:118767. doi: 10.1016/j.envres.2024.118767. Online ahead of print.ABSTRACTThere is unclear evidence available on the associations between multiple metals and fasting blood glucose (FBG) in children, and whether they could be beneficial from physical activity. We included 283 children aged 4-12 years from two panel studies with 4-consecutive morning urinary 13 essential metals and 10 non-essential metals repeated across 3 seasons. We employed multiple inform model, linear mixed model, and quantile g-computation to evaluate associations of single metal and their mixture with FBG and interactions with extra-school activity. The results showed that positive relations of multiple essential metals (aluminum, chromium, copper, iron, molybdenum, nickel, selenium, strontium, zinc) and non-essential metals (arsenic (As), cadmium, rubidium, titanium, thallium) with FBG were the strongest at lag 0 (the health examination day), especially in overweight & obesity children (FDR <0.05). The strongest effects presented 1-fold increment in As was related to FBG increased 1.66% (95%CI: 0.84%, 2.48%) in overweight & obesity children. Notably, modification of extra-school activity showed significant, and the effect of multiple metals on FBG were attenuated in children taking total extra-school activity ≥1 h/day, and only one type of which, low or moderate & high intensity extra-school activity reached 20 min/day (Pint <0.05). For instance, each 1-fold i...
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research