CRISPR/Cas9 Genome Editing Allows Generation of the Mouse Lung in a Rat

CONCLUSIONS: A combination of CRISPR/Cas9 genome editing and blastocyst complementation was used to produce mouse lungs in rats, making an important step toward future generations of human lungs using large animals as "bioreactors".PMID:38507610 | DOI:10.1164/rccm.202306-0964OC

Source: American Journal of Respiratory and Critical Care Medicine - March 20, 2024 Category: Respiratory Medicine Authors: Bingqiang Wen Enhong Li Guolun Wang Timothy R Kalin Dongfeng Gao Peixin Lu Tanya V Kalin Vladimir V Kalinichenko Source Type: research