The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats

CONCLUSIONS: Our results indicate that a single administration of VPA in the PTZ-kindled rats restored proper balance between excitatory (decreasing the level of ASP) and inhibitory neurotransmission (increased concentration GABA, KYNA) and affecting serotoninergic neurotransmission in the prefrontal cortex, hippocampus, amygdala, and striatum.PMID:38519733 | DOI:10.1007/s43440-024-00573-w

Source: Pharmacological Reports - March 23, 2024 Category: Drugs & Pharmacology Authors: Aleksandra Wis łowska-Stanek Danuta Turzy ńska Alicja Sobolewska Karolina Ko łosowska Janusz Szyndler Anna Sk órzewska Piotr Maciejak Source Type: research