DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer

ConclusionThis study unveils a novel epigenetic phenotype in CRC linked to resistance against immune checkpoint inhibitors, presenting a significant step toward personalized medicine by suggesting epigenetic classifications as a means to identify ideal candidates for immunotherapy in CRC. Our findings also highlight potential therapeutic agents for the DMP subtype, offering new avenues for tailored CRC treatment strategies.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research