Cefazolin as the Mainstay for Antibiotic Prophylaxis in Penicillin Allergic Patients in Obstetrics and Gynecology

Cefazolin is the most common antibiotic used for prophylaxis in obstetrics and gynecology. Among those with a penicillin allergy, alternative antibiotics are often chosen for prophylaxis given fears of cross-reactivity between penicillin and cefazolin. Alternative antibiotics in this setting are associated with adverse sequalae including surgical site infection, induction of bacterial resistance, higher costs to the healthcare system, and possible Clostridium difficile infection. Given the difference in R1 side chains between the penicillin and cefazolin, cefazolin use is safe and should be recommended for penicillin allergic patients including those who experience IgE-mediated reactions such as anaphylaxis.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Clinical Opinion Source Type: research