Gut Microbial Dysbiosis in the Pathogenesis of Leukemia: An Immune-based Perspective

A growing body of evidence points to the role of various human gut microbes in the genesis and progression of different cancers and hematological diseases including leukemia. This is carried out by both direct and indirect mechanisms [1]. For example, the bacterial species of Fusobacterium nucleatum directly binds to E-cadherin through its adhesin factor FadA (Fusobacterium adhesin A) thereby triggering the process of tumorigenesis in colorectal cancer [2]. Indirectly, the gut microbiota, with its constant provocation of the immune system, may lead into the development of cancer by creating a pro-inflammatory state within the host body [3].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research