Post-transfusion biotin-labeled red blood cell survival studies in pediatric sickle cell disease with antibodies of uncertain significance

DISCUSSION: Biotinylation of allogenic RBC can be used to assess the possible effects of RBC antibodies on transfusion survival in individual cases, particularly when it is uncertain if the detected antibodies may result in hemolysis. In the cases presented here, neither WAA nor B-RBC antibodies were associated with significant shortening of B-RBC survival in individuals with SCD.PMID:38506450 | DOI:10.1111/trf.17800

Source: Transfusion - March 20, 2024 Category: Hematology Authors: Marianne E M Yee Patricia E Zerra James W McCoy Mischa L Covington Sean R Stowell Clinton H Joiner Christopher M Lough Bhaveshkumar B Delvadia Cassandra D Josephson John D Roback Ross M Fasano Source Type: research