Subolesin knockdown in tick cells provides insights into vaccine protective mechanisms

In this study, transcriptomics and proteomics analyses were conducted together with graph theory data analysis in wild type and Sub knockdown (KD) tick ISE6 cells in order to identify and characterize the functional implications of Sub in tick cells. The results support a key role for Sub in the regulation of gene expression in ticks and the relevance of this antigen in vaccine development against ticks and TBDs. Proteins with differential representation in response to Sub KD provide insights into vaccine protective mechanisms and candidate tick protective antigens.PMID:38508929 | DOI:10.1016/j.vaccine.2024.03.006
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research