Alternative polyadenylation determines the functional landscape of inverted Alu repeats

Ku et  al. capture and map the dsRNA structures in the transcriptome to study the pathophysiological role of gene silencing by 3′ UTR IRAlus. Specifically, tumors can suppress p53 via IRAlus exclusion through shortening of MDM2 3′ UTR, whereas global enhancement of IRAlus-mediated gene silencing is a ssociated with neurodegenerative diseases.

Source: Molecular Cell - February 2, 2024 Category: Cytology Authors: Jayoung Ku, Keonyong Lee, Doyeong Ku, Sujin Kim, Jongbin Lee, Hyunwoo Bang, Namwook Kim, Hyunsu Do, Hyeonjung Lee, Chunghun Lim, Jinju Han, Young-suk Lee, Yoosik Kim Tags: Article Source Type: research