Brown Adipose Tissue Metabolism in Women is Dependent on Ovarian Status

Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00077.2024. Online ahead of print.ABSTRACTIn rodents, loss of estradiol (E2) reduces brown adipose tissue (BAT) metabolic activity. Whether E2 impacts BAT activity in women is not known. BAT oxidative metabolism was measured in premenopausal (N=27, 35±9 years, body mass index (BMI) = 26.0±5.3 kg/m2) and postmenopausal (N=25, 51±8 years, BMI = 28.0±5.0 kg/m2) women at room temperature (RT) and during acute cold exposure using [11C]-acetate with positron emission tomography coupled with computed tomography (PET/CT). BAT glucose uptake was also measured during acute cold exposure using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). To isolate the effects of ovarian hormones from biological aging, measurements were repeated in a subset of premenopausal women (N=8, 40±4 years, BMI = 28.0±7.2 kg/m2) after 6 months of gonadotropin-releasing hormone agonist (GnRHAG) therapy to suppress ovarian hormones. At RT, there was no difference in BAT oxidative metabolism between premenopausal (0.56±0.31.min-1) and postmenopausal women (0.63±0.28.min-1). During cold exposure, BAT oxidative metabolism (1.28±0.85 vs. 0.91±0.63.min-1, P=0.03) and net BAT glucose uptake (84.4±82.5 vs. 29.7±31.4 nmol.g-1.min-1, P<0.01) were higher in premenopausal than postmenopausal women. In premenopausal women who underwent GnRHAG, cold-stimulated BAT oxidative metabolism was reduced to a similar level (from 1.36±0.66.min-1 to 0.91±0.4...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Source Type: research