EV-mediated intercellular communication in acute myeloid leukemia: Transport of genetic materials in the bone marrow microenvironment

Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. It occurs due to the proliferation of nonfunctional primitive myeloid cells in the bone marrow (BM), which further spread to other parts of the body, such as the blood, liver, spleen, and central nervous system [1]. Inadequate understanding of the pathophysiology of AML as well as the lack of specific diagnostic and therapeutic monitoring tools limit the therapeutic effect [2,3].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research