Germline Cancer Susceptibility in Individuals with Melanoma
Inherited melanoma is not rare: approximately 1 in 7 individuals with melanoma harbored clinically relevant hereditable cancer susceptibility in a prospective cross-sectional study, with 3 validation cohorts supporting 10-16% incidence. We recommend obtaining family history inclusive of non-cutaneous cancers and considering genetics referral for ≥2 melanomas/cancers to increase diagnostic yield.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: P. Funchain, Y. Ni, B. Heald, B. Bungo, M. Arbesman, T.R. Behera, S. McCormick, J.M. Song, L.B. Kennedy, S.M. Nielsen, E.D. Esplin, E. Nizialek, J. Ko, C.M. Diaz-Montero, B. Gastman, A.J. Stratigos, M. Artomov, H. Tsao, J. Arbesman Source Type: research
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