Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib ΔC-X mice with persistent atrial fibrillation

Overexpression of the CREM (cAMP response element-binding modulator) isoform CREM-Ib ΔC-X in transgenic mice (CREM-Tg) causes the age-dependent development of spontaneous AF.

Source: Journal of Molecular and Cellular Cardiology - March 19, 2024 Category: Cytology Authors: Shuai Zhao, Mohit M. Hulsurkar, Satadru K. Lahiri, Yuriana Aguilar-Sanchez, Elda Munivez, Frank Ulrich M üller, Antrix Jain, Anna Malovannaya, Kendrick Yiu, Svetlana Reilly, Xander H.T. Wehrens Source Type: research