Efficacy of intravenous high-dose methotrexate in preventing relapse to the central nervous system in R-CHOP(-like)-treated, high-risk, diffuse large B-cell lymphoma patients and its effect on mortality: a systematic review and meta-analysis
CONCLUSION: Our data indicate that HD-MTX does not prevent, or at best, only slightly reduces the risk of CNS relapse and confers no survival benefit.PMID:38497149 | DOI:10.3324/haematol.2023.284281
Source: Haematologica - Category: Hematology Authors: Elisabeth R Tolley Christian Lewinter Lars M Pedersen Torsten Holm Nielsen Source Type: research