Infantile myofibromatosis in a 5-month-old boy

A 5-month-old boy presented with a solitary occipital growth. The lesion was of hard consistency, immobile, painless, measuring 2x3 cm with no relevant lymph node involvement. The overlying skin was intact. There was no relevant family history. Ultrasound scan revealed a bony lytic lesion. Initial CT and MRIs were suspicious of Langerhans cell histiocytosis. The lesion was indenting into cerebellar hemispheres, contacting but not indenting the venous sinuses (figure 1). No abnormal brain parenchymal signal was identified. Histopathology examination showed interlacing fascicles of spindle cells with myofibroblastic morphology confirming infantile myofibroma (IM). A full body MRI excluded other lesions. A follow-up MRI with contrast 2 months later showed a minor 3 mm enlargement (figure 2). IM is a rare tumour which presents as slow-growing, solitary or multiple lumps on the head, neck or trunk, and less commonly internal organs.1 IM is caused by...

Source: Archives of Disease in Childhood - March 19, 2024 Category: Pediatrics Authors: Mohammad, O., Jacoby, J., Tighe, M. P. Tags: Miscellanea Source Type: research