Multi-omics characterization of healthy and PSC human liver – what we knew and what we have learned

To date, we have not fully understood the pathogenesis of primary sclerosing cholangitis (PSC), a dreadful progressive cholestatic disease associated with an increased risk of bacterial cholangitis and malignancies, such as cholangiocarcinoma and colorectal carcinoma, for which effective treatment options are lacking.1,2 Several reports and genetic association studies have pointed toward a dysregulation of the adaptive immune response in PSC,3 –5 but deeper functional insights into the immune pathogenesis have been hampered by the availability of sufficient amounts of human liver tissue, especially from early-disease stages and the lack of techniques to comprehensively assess the plethora of immune and parenchymal cell populations and t heir interactions (Fig. 1).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research