Cancers, Vol. 16, Pages 1186: Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis

Conclusions: Phase-specific differential NK cell activity in BRCA1 mutation carriers, either systemically or locally, may favor site-specific pre-invasive carcinogenesis. These cumulative effects across a reproductive lifecycle in high-risk carriers can have a detrimental effect further supporting epidemiological evidence for ovulation inhibition.

Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Shaun Haran Kantaraja Chindera May Sabry Nafisa Wilkinson Rupali Arora Agnieszka Zubiak Thomas E. Bartlett Iona Evans Allison Jones Daniel Reisel Chiara Herzog Twana Alkasalias Mark Newman Jaeyeon Kim Angelique Fl öter Rådestad Kristina Gemzell-Danielss Tags: Article Source Type: research