Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease

CONCLUSIONS: Our observations imply that exercise intervention dropout is genetically moderated through alterations in gene expression and metabolic pathways in skeletal muscle. Individual genetic traits may allow the development of a biomarker-based approach for identifying individuals who may benefit from more intensive counseling and other interventions to optimize exercise intervention adoption.CLINICAL TRIAL INFORMATION: STRRIDE I = NCT00200993; STRRIDE AT/RT = NCT00275145; STRRIDE-PD = NCT00962962.PMID:38489667 | DOI:10.1093/abm/kaae011

Source: Annals of Behavioral Medicine - March 15, 2024 Category: Psychiatry & Psychology Authors: Rong Jiang Katherine A Collins Kim M Huffman Elizabeth R Hauser Monica J Hubal Johanna L Johnson Redford B Williams Ilene C Siegler William E Kraus Source Type: research