Synthesis and initial < em > in vitro < /em > evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer

CONCLUSION: The cytotoxicity effect of I-OTB was comparable to that of OTB. This result indicates that the iodine substituent in OTB did not alter the parent compound selectivity toward double mutations EGFR L858R/T790M. Therefore, I-OTB is prominent for radioiodination, and [123/124I] I-OTB may be a promising candidate for EGFR L858R/T790M mutation imaging.PMID:38327635 | PMC:PMC10844591 | DOI:10.34172/bi.2023.27774

Source: BioImpacts - February 8, 2024 Category: Research Authors: Muammar Fawwaz Kenji Mishiro Arwansyah Arwansyah Ryuichi Nishii Kazuma Ogawa Source Type: research